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What is OPSUMIT®?

OPSUMIT® is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT® can:

The most important information about OPSUMIT® (macitentan)

Do not take OPSUMIT® if you are pregnant or trying to get pregnant. OPSUMIT® can cause serious birth defects if taken while pregnant.

Women who are able to get pregnant must have negative pregnancy tests:




Support from our PAH Companions

The PAH Companion Program* provides one-on-one educational support to help you start and stay on your prescribed Janssen PAH medication, provide resources to partner with your healthcare team, and help you better manage your pulmonary arterial hypertension (PAH).

Look to the PAH Companion Program for:

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Tools to help you have more productive discussions with your healthcare team

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Tips for engaging with your support network and peers

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Ongoing education on managing and living with PAH

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Connection with a dedicated PAH Companion through email, phone, and/or text

As part of the program, PAH Companions are ready to answer your questions. Patients who have enrolled can talk to a PAH Companion by calling 866-300-1818, Monday-Friday, 8 AM-9 PM ET.

Visit PAHCompanion.com to learn more

*The PAH Companion Program is limited to education about your Janssen PAH therapy, its administration, and/or PAH. It is intended to supplement your understanding of your therapy, and does not provide medical advice or replace a treatment plan from your doctor, nurse, or healthcare team.

See More

What is OPSUMIT®?

OPSUMIT® is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT® can:

  • Improve your ability to exercise as measured by the 6-minute walk distance (6MWD). In a clinical study of mainly WHO FC II-III patients, those taking OPSUMIT® walked, on average, 22 meters farther at Month 6 than patients not taking it

The most important information about OPSUMIT® (macitentan)

Do not take OPSUMIT® if you are pregnant or trying to get pregnant. OPSUMIT® can cause serious birth defects if taken while pregnant.

Women who are able to get pregnant must have negative pregnancy tests:

  • Before starting OPSUMIT®
  • Each month while taking OPSUMIT®
  • For 1 month after stopping OPSUMIT®